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Please use this identifier to cite or link to this item:
http://ricaxcan.uaz.edu.mx/jspui/handle/20.500.11845/2677
Title: | CYP2D6 gene polymorphisms and predicted phenotypes in eight indigenous groups from northwestern Mexico |
Authors: | Lazalde Ramos, Blanca Patricia Martínez Fierro, Margarita de la Luz Galaviz Hernández, Carlos Garza Veloz, Idalia Naranjo, María Eugenia Sosa Macías, Martha Llerena, Adrián |
Issue Date: | 17-Feb-2014 |
Publisher: | Future Medicine Ltd |
Abstract: | Aim: Polymorphisms in CYP2D6 impact the interindividual and interethnic variability of drug efficiency; therefore, we determined the CYP2D6 allele distribution in eight Amerindian groups from northwestern Mexico and compared them with the frequencies in Mexican Mestizos. Materials & methods: A total of 508 Amerindians were studied. Genotyping of CYP2D6 5 and multiplication alleles was performed by long-range PCR, while CYP2D62,3,4,6,10,17,29,35,41 and copy number were evaluated by real-time PCR. Results: The most frequent alleles were CYP2D62 (0.05-0.28), CYP2D64 (0.003-0.21) and multiplications (0.043-0.107). CYP2D65,6, * 10 and41 were not observed in the majority of Amerindians, and CYP2D63,17,35 and29 were not detected. The poor metabolizer genotype (4/5) was lower (0.2%) in Amerindians than in Mestizos (5%); conversely, the ultrarapid metabolizer genotype was higher (12.6%) in indigenous groups than in Mestizos (7%). Conclusion: Our data show a lower frequency of CYP2D6 inactive alleles and a higher frequency of duplication/multiplication of CYP2D6 active alleles in indigenous populations that in Mestizos. |
URI: | http://ricaxcan.uaz.edu.mx/jspui/handle/20.500.11845/2677 https://doi.org/10.48779/ha9s-z852 |
ISSN: | 1462-2416 1744-8042 |
Other Identifiers: | info:eu-repo/semantics/publishedVersion |
Appears in Collections: | *Documentos Académicos*-- M. en Ciencias y Tecnología Química |
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CYP2D6 gene polymorphisms and predicted.pdf | 1,2 MB | Adobe PDF | View/Open |
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