Please use this identifier to cite or link to this item: http://ricaxcan.uaz.edu.mx/jspui/handle/20.500.11845/2677
Title: CYP2D6 gene polymorphisms and predicted phenotypes in eight indigenous groups from northwestern Mexico
Authors: Lazalde Ramos, Blanca Patricia
Martínez Fierro, Margarita de la Luz
Galaviz Hernández, Carlos
Garza Veloz, Idalia
Naranjo, María Eugenia
Sosa Macías, Martha
Llerena, Adrián
Issue Date: 17-Feb-2014
Publisher: Future Medicine Ltd
Abstract: Aim: Polymorphisms in CYP2D6 impact the interindividual and interethnic variability of drug efficiency; therefore, we determined the CYP2D6 allele distribution in eight Amerindian groups from northwestern Mexico and compared them with the frequencies in Mexican Mestizos. Materials & methods: A total of 508 Amerindians were studied. Genotyping of CYP2D6 5 and multiplication alleles was performed by long-range PCR, while CYP2D62,3,4,6,10,17,29,35,41 and copy number were evaluated by real-time PCR. Results: The most frequent alleles were CYP2D62 (0.05-0.28), CYP2D64 (0.003-0.21) and multiplications (0.043-0.107). CYP2D65,6, * 10 and41 were not observed in the majority of Amerindians, and CYP2D63,17,35 and29 were not detected. The poor metabolizer genotype (4/5) was lower (0.2%) in Amerindians than in Mestizos (5%); conversely, the ultrarapid metabolizer genotype was higher (12.6%) in indigenous groups than in Mestizos (7%). Conclusion: Our data show a lower frequency of CYP2D6 inactive alleles and a higher frequency of duplication/multiplication of CYP2D6 active alleles in indigenous populations that in Mestizos.
URI: http://ricaxcan.uaz.edu.mx/jspui/handle/20.500.11845/2677
https://doi.org/10.48779/ha9s-z852
ISSN: 1462-2416
1744-8042
Other Identifiers: info:eu-repo/semantics/publishedVersion
Appears in Collections:*Documentos Académicos*-- M. en Ciencias y Tecnología Química

Files in This Item:
File Description SizeFormat 
CYP2D6 gene polymorphisms and predicted.pdf1,2 MBAdobe PDFView/Open


This item is licensed under a Creative Commons License Creative Commons