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Please use this identifier to cite or link to this item:
http://ricaxcan.uaz.edu.mx/jspui/handle/20.500.11845/2677
Full metadata record
DC Field | Value | Language |
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dc.contributor | 46461 | es_ES |
dc.contributor.other | https://orcid.org/0000-0002-1995-1696 | - |
dc.coverage.spatial | México | es_ES |
dc.creator | Lazalde Ramos, Blanca Patricia | - |
dc.creator | Martínez Fierro, Margarita de la Luz | - |
dc.creator | Galaviz Hernández, Carlos | - |
dc.creator | Garza Veloz, Idalia | - |
dc.creator | Naranjo, María Eugenia | - |
dc.creator | Sosa Macías, Martha | - |
dc.creator | Llerena, Adrián | - |
dc.date.accessioned | 2021-06-29T16:39:34Z | - |
dc.date.available | 2021-06-29T16:39:34Z | - |
dc.date.issued | 2014-02-17 | - |
dc.identifier | info:eu-repo/semantics/publishedVersion | es_ES |
dc.identifier.issn | 1462-2416 | es_ES |
dc.identifier.issn | 1744-8042 | es_ES |
dc.identifier.uri | http://ricaxcan.uaz.edu.mx/jspui/handle/20.500.11845/2677 | - |
dc.identifier.uri | https://doi.org/10.48779/ha9s-z852 | - |
dc.description.abstract | Aim: Polymorphisms in CYP2D6 impact the interindividual and interethnic variability of drug efficiency; therefore, we determined the CYP2D6 allele distribution in eight Amerindian groups from northwestern Mexico and compared them with the frequencies in Mexican Mestizos. Materials & methods: A total of 508 Amerindians were studied. Genotyping of CYP2D6 5 and multiplication alleles was performed by long-range PCR, while CYP2D62,3,4,6,10,17,29,35,41 and copy number were evaluated by real-time PCR. Results: The most frequent alleles were CYP2D62 (0.05-0.28), CYP2D64 (0.003-0.21) and multiplications (0.043-0.107). CYP2D65,6, * 10 and41 were not observed in the majority of Amerindians, and CYP2D63,17,35 and29 were not detected. The poor metabolizer genotype (4/5) was lower (0.2%) in Amerindians than in Mestizos (5%); conversely, the ultrarapid metabolizer genotype was higher (12.6%) in indigenous groups than in Mestizos (7%). Conclusion: Our data show a lower frequency of CYP2D6 inactive alleles and a higher frequency of duplication/multiplication of CYP2D6 active alleles in indigenous populations that in Mestizos. | es_ES |
dc.language.iso | spa | es_ES |
dc.publisher | Future Medicine Ltd | es_ES |
dc.relation | https://ipn.elsevierpure.com/es/publications/cyp2d6-gene-polymorphisms-and-predicted-phenotypes-in-eight-indig | es_ES |
dc.relation.ispartof | https://doi.org/10.2217/pgs.13.203 | es_ES |
dc.relation.uri | generalPublic | es_ES |
dc.rights | Atribución-NoComercial-CompartirIgual 3.0 Estados Unidos de América | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/3.0/us/ | * |
dc.source | Pharmacogenomics, Vol 15, No. 3, 339-348. | es_ES |
dc.subject.classification | BIOLOGIA Y QUIMICA [2] | es_ES |
dc.subject.other | drug efficiency | es_ES |
dc.subject.other | Mexican Mestizos | es_ES |
dc.subject.other | CYP2D6 | es_ES |
dc.title | CYP2D6 gene polymorphisms and predicted phenotypes in eight indigenous groups from northwestern Mexico | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
Appears in Collections: | *Documentos Académicos*-- M. en Ciencias y Tecnología Química |
Files in This Item:
File | Description | Size | Format | |
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CYP2D6 gene polymorphisms and predicted.pdf | 1,2 MB | Adobe PDF | View/Open |
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