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Title: Anti‑inflammatory drugs and uterine cervical cancer cells: Antineoplastic effect of meclofenamic acid
Authors: Soriano Hernandez, Alejandro
Madrigal Pérez, Daniela
Galván Salazar, Héctor
Martínez Fierro, Margarita de la Luz
Valdez Velazquez, Laura
Espinoza Gómez, Francisco
Vázquez Vuelvas, Oscar
Olmedo Buenrostro, Bertha
Guzmán Esquivel, José
Rodríguez Sánchez, Iram Pablo
Lara Esqueda, Agustín
Montes Galindo, Daniela
Delgado Enciso, Iván
Issue Date: Aug-2015
Publisher: Spandidos publications
Abstract: Uterine cervical cancer (UCC) is one of the main causes of cancer-associated mortality in women. Inflammation has been identified as an important component of this neoplasia; in this context, anti-inflammatory drugs represent possible prophylactic and/or therapeutic alternatives that require further investigation. Anti-inflammatory drugs are common and each one may exhibit a different antineoplastic effect. As a result, the present study investigated different anti-inflammatory models of UCC in vitro and in vivo. Celecoxib, sulindac, nimesulide, dexamethasone, meclofenamic acid, flufenamic acid and mefenamic acid were tested in UCC HeLa, VIPA, INBL and SiHa cell lines. The cytotoxicity of the drugs was evaluated in vitro. Celecoxib, sulindac, nimesulide, mefenamic acid and flufenamic acid presented with slight to moderate toxicity (10–40% of cell death corresponding to 100 µM) in certain cell lines, while meclofenamic acid exhibited significant cytotoxicity in all essayed cell lines (50–90% of cell death corresponding to 100 µM). The meclofenamic acid was tested in murine models (immunodeficient and immunocompetent) of UCC, which manifested a significant reduction in tumor growth and increased mouse survival. It was demonstrated that of the evaluated anti-inflammatory drugs, meclofenamic acid was the most cytotoxic, with a significant antitumor effect in murine models. Subsequent studies are necessary to evaluate the clinical utility of this drug.
ISSN: 1792-1074
Other Identifiers: info:eu-repo/semantics/publishedVersion
Appears in Collections:*Documentos Académicos*-- Doc. en Ing. y Tec. Aplicada

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