Please use this identifier to cite or link to this item: http://ricaxcan.uaz.edu.mx/jspui/handle/20.500.11845/1479
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dc.contributor49237es_ES
dc.coverage.spatialGlobales_ES
dc.creatorSoriano Hernandez, Alejandro-
dc.creatorMadrigal Pérez, Daniela-
dc.creatorGalván Salazar, Héctor-
dc.creatorMartínez Fierro, Margarita de la Luz-
dc.creatorValdez Velazquez, Laura-
dc.creatorEspinoza Gómez, Francisco-
dc.creatorVázquez Vuelvas, Oscar-
dc.creatorOlmedo Buenrostro, Bertha-
dc.creatorGuzmán Esquivel, José-
dc.creatorRodríguez Sánchez, Iram Pablo-
dc.creatorLara Esqueda, Agustín-
dc.creatorMontes Galindo, Daniela-
dc.creatorDelgado Enciso, Iván-
dc.date.accessioned2020-03-31T20:48:48Z-
dc.date.available2020-03-31T20:48:48Z-
dc.date.issued2015-08-
dc.identifierinfo:eu-repo/semantics/publishedVersiones_ES
dc.identifier.issn1792-1074es_ES
dc.identifier.issn1792-1082es_ES
dc.identifier.urihttp://ricaxcan.uaz.edu.mx/jspui/handle/20.500.11845/1479-
dc.description.abstractUterine cervical cancer (UCC) is one of the main causes of cancer-associated mortality in women. Inflammation has been identified as an important component of this neoplasia; in this context, anti-inflammatory drugs represent possible prophylactic and/or therapeutic alternatives that require further investigation. Anti-inflammatory drugs are common and each one may exhibit a different antineoplastic effect. As a result, the present study investigated different anti-inflammatory models of UCC in vitro and in vivo. Celecoxib, sulindac, nimesulide, dexamethasone, meclofenamic acid, flufenamic acid and mefenamic acid were tested in UCC HeLa, VIPA, INBL and SiHa cell lines. The cytotoxicity of the drugs was evaluated in vitro. Celecoxib, sulindac, nimesulide, mefenamic acid and flufenamic acid presented with slight to moderate toxicity (10–40% of cell death corresponding to 100 µM) in certain cell lines, while meclofenamic acid exhibited significant cytotoxicity in all essayed cell lines (50–90% of cell death corresponding to 100 µM). The meclofenamic acid was tested in murine models (immunodeficient and immunocompetent) of UCC, which manifested a significant reduction in tumor growth and increased mouse survival. It was demonstrated that of the evaluated anti-inflammatory drugs, meclofenamic acid was the most cytotoxic, with a significant antitumor effect in murine models. Subsequent studies are necessary to evaluate the clinical utility of this drug.es_ES
dc.language.isoenges_ES
dc.publisherSpandidos publicationses_ES
dc.relationhttps://www.spandidos-publications.com/oles_ES
dc.relation.urigeneralPublices_ES
dc.rightsAtribución-NoComercial-CompartirIgual 3.0 Estados Unidos de América*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.sourceOncology letters, Vol. 10, No 4, 2015, pp. 2574–2578.es_ES
dc.subject.classificationMEDICINA Y CIENCIAS DE LA SALUD [3]es_ES
dc.subject.othernon-steroidal anti-inflamatory drugses_ES
dc.subject.othermeclofenamic acides_ES
dc.subject.otherantitumor activityes_ES
dc.subject.otheruterine cervical canceres_ES
dc.subject.othermurine modeles_ES
dc.titleAnti‑inflammatory drugs and uterine cervical cancer cells: Antineoplastic effect of meclofenamic acides_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
Appears in Collections:*Documentos Académicos*-- Doc. en Ing. y Tec. Aplicada

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