Ochoa González, Fátima; Cervantes Villagrana, Alberto Rafael; Fernandez Ruíz, Julio C.; Nava Ramírez, Hilda S.; Hernández Correa, Adriana C.; Enciso Moreno, Jose A.; Castañeda Delgado, Julio E.
Resumen:
Several epidemiological studies in diabetic patients have demonstrated a protective effect
of metformin to the development of several types of cancer. The underlying mechanisms of
such phenomenon is related to the effect of metformin on cell proliferation among which,
mTOR, AMPK and other targets have been identified. However, little is known about the
role that metformin treatment have on other cell types such as keratinocytes and whether
exposure to metformin of these cells might have serious repercussions in wound healing
delay and in the development of complications in diabetic patients with foot ulcers or in their
exacerbation.