Please use this identifier to cite or link to this item: http://ricaxcan.uaz.edu.mx/jspui/handle/20.500.11845/2546
Title: Metformin Induces Cell Cycle Arrest, Reduced Proliferation, Wound Healing Impairment In Vivo and Is Associated to Clinical Outcomes in Diabetic Foot Ulcer Patients
Authors: Ochoa González, Fátima
Cervantes Villagrana, Alberto Rafael
Fernandez Ruíz, Julio C.
Nava Ramírez, Hilda S.
Hernández Correa, Adriana C.
Enciso Moreno, Jose A.
Castañeda Delgado, Julio E.
Issue Date: 10-Mar-2016
Publisher: Harvard Medical School
Abstract: Several epidemiological studies in diabetic patients have demonstrated a protective effect of metformin to the development of several types of cancer. The underlying mechanisms of such phenomenon is related to the effect of metformin on cell proliferation among which, mTOR, AMPK and other targets have been identified. However, little is known about the role that metformin treatment have on other cell types such as keratinocytes and whether exposure to metformin of these cells might have serious repercussions in wound healing delay and in the development of complications in diabetic patients with foot ulcers or in their exacerbation.
URI: http://ricaxcan.uaz.edu.mx/jspui/handle/20.500.11845/2546
ISSN: 1932-6203
Other Identifiers: info:eu-repo/semantics/publishedVersion
Appears in Collections:*Documentos Académicos*-- M. en Ciencias y Tecnología Química

Files in This Item:
File Description SizeFormat 
MEtformin PLos One.pdf864,99 kBAdobe PDFView/Open


This item is licensed under a Creative Commons License Creative Commons