Please use this identifier to cite or link to this item: http://ricaxcan.uaz.edu.mx/jspui/handle/20.500.11845/2613
Title: Genome Damage in Rats after Transplacental Exposure to Jatropha dioica Root Extract
Authors: Morales Velazquez, Gabriela
Lazalde Ramos, Blanca Patricia
Gómez Meda, Belinda Claudia
Zuñiga González, Guillermo Moisés
Ortíz García, Yveth Marlene
Gutiérrez Hernández, Rosalinda
Guerrero Velazquez, Celia
Sánchez de la Rosa, Susana Vanessa
Zamora Pérez, Ana Lourdes
Issue Date: 3-Nov-2019
Publisher: Hindawi
Abstract: Jatropha dioica is traditionally used owing to its antiviral, antifungal, and antimicrobial properties. But, toxicological information regarding J. dioica root total extract is currently limited. The aim of this work was to evaluate in a rat model, the transplacental genotoxicity effect of J. dioica aqueous root total extract. Three different J. dioica aqueous root total extract doses (60, 100, and 300 mg/kg) were administered orally to Wistar rats during 5 days through the pregnancy term (16–21 days). Pregnant rats were sampled every 24 h during the last 6 days of gestation, and pubs were sampled at birth. Genome damage in dams and their newborn pups transplacentally exposed to J. dioica was evaluated by in vivo micronuclei assay. We evaluated the frequency of micronucleated erythrocytes (MNE), micronucleated polychromatic erythrocytes (MNPCE), and polychromatic erythrocytes (PCE) in peripheral blood samples from pups and MNPCE and PCE in pregnant rats. No genotoxic effect was observed after oral administration of the three different doses of aqueous root total extract of J. dioica in pregnant or in their newborn pubs, after transplacental exposure. A significant decrease in PCE frequency was noted in samples from pubs of rats treated with the highest dose of J. dioica extract. The aqueous total root extract of J. dioica at the highest dose tested in our research do have cytotoxic effect in pups transplacentally exposed to this plant extract. Moreover, neither a genotoxic nor a cytotoxic effect was observed in pregnant rats. In the present work, there was no evidence of genome damage in the rat model after transplacental exposure to J. dioica aqueous root total extract.
URI: http://ricaxcan.uaz.edu.mx/jspui/handle/20.500.11845/2613
https://doi.org/10.48779/xgcn-9k92
ISSN: 1741-427X
1741-4288
Other Identifiers: info:eu-repo/semantics/publishedVersion
Appears in Collections:*Documentos Académicos*-- M. en Ciencias y Tecnología Química

Files in This Item:
File Description SizeFormat 
Genome Damage in Rats after Transplacental Exposure to Jatropha dioica Root Extract.pdf2,07 MBAdobe PDFView/Open


This item is licensed under a Creative Commons License Creative Commons