Please use this identifier to cite or link to this item:
Title: An Animal Model Using Metallic Ions to Produce Autoimmune Nephritis
Authors: Ramírez Sandova, Roxana
Luévano Rodríguez, Nayeli
Rodríguez Rodríguez, Mayra
Pérez Pérez, María Elena
Saldívar Elias, Sergio
Gurrola Carlos, Reinaldo
Avalos Díaz, Esperanza del Refugio
Bollain y Goytia, Juan José
Herrera Esparza, Rafael
Issue Date: 2015
Publisher: Hindawi
Abstract: Autoimmune nephritis triggered by metallic ions was assessed in a Long-Evans rat model. The parameters evaluated included antinuclear autoantibody production, kidney damage mediated by immune complexes detected by immunofluorescence, and renal function tested by retention of nitrogen waste products and proteinuria. To accomplish our goal, the animals were treated with the following ionic metals: HgCl2, CuSO4, AgNO3, and Pb(NO3)2. A group without ionic metals was used as the control. The results of the present investigation demonstrated that metallic ions triggered antinuclear antibody production in 60% of animals, some of them with anti-DNA specificity. Furthermore, all animals treated with heavy metals developed toxic glomerulonephritis with immune complex deposition along the mesangium and membranes. These phenomena were accompanied by proteinuria and increased concentrations of urea. Based on these results, we conclude that metallic ions may induce experimental autoimmune nephritis.
ISSN: 23148861
Other Identifiers: info:eu-repo/semantics/publishedVersion
Appears in Collections:*Documentos Académicos*-- UA Medicina

Files in This Item:
File Description SizeFormat 
An Animal Model Using Metallic Ions to Produce.pdf8,27 MBAdobe PDFView/Open

This item is licensed under a Creative Commons License Creative Commons