Please use this identifier to cite or link to this item: http://ricaxcan.uaz.edu.mx/jspui/handle/20.500.11845/2180
Title: Apoptosis in chronic cutaneous lupus erythematosus, discoid lupus, and lupus profundus
Authors: Sáenz Corral, Claudia Ileana
Vega Memíje, María Elisa
Martínez Luna, Eduwiges
Cuevas González, Juan Carlos
Rodríguez Carreón, Alma Angélica
Bollain y Goytia, Juan José
Felipe de Jesús, Torres del Muro
Avalos Díaz, Esperanza del Refugio
Issue Date: 2015
Publisher: e-Century Publishing Corporation
Abstract: : Introduction: Lupus erythematosus is a multisystemic disease that is characterized by autoantibody production and immune complex deposition in such tissues as the mucosa, joints, the central nervous system, and skin. Cutaneous lupus erythematosus is categorized as acute, subacute, and chronic. Chronic cutaneous lupus erythematosus comprises discoid lupus erythematosus (DLE) and lupus profundus (LP). Aim: To analyze the expression of proapoptotic molecules in patients with lupus erythematosus discoid and lupus profundus. Material and methods: Descriptive study, the study groups comprised 10 cases of LP and 10 cases of DLE, and a control. Skin samples of cases and controls were processed for immunohistochemistry and by TUNEL technique. The database and statistical analysis was performed (statistical test X2) SPSS (Chicago, IL, USA). Results: Apoptotic features were broadly distributed along the skin biopsies in epidermal keratinocytes as well as at dermis. By immunohistochemistry the expression of Fas receptor and Fas-L was higher in the skin of lupus patients compared with controls. We also noted differences in Fas-L, -Fas, and -Bax proteins expression intensity in discoid lupus erythematosus patients in the epidermis, and hair follicles. Conclusions: Fas and Fas-L are expressed similarly in LP and DLE.
URI: http://ricaxcan.uaz.edu.mx/jspui/handle/20.500.11845/2180
https://doi.org/10.48779/2th4-a116
ISSN: 1936-2625
Other Identifiers: info:eu-repo/semantics/publishedVersion
Appears in Collections:*Documentos Académicos*-- UA Medicina

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