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Title: Posttranslational Protein Modification in the Salivary Glands of Sjögren’s Syndrome Patients
Authors: Herrera Esparza, Rafael
Rodríguez Rodríguez, Mayra
Pérez Pérez, María Elena
Badillo Soto, Martha Adriana
Torres del Muro, Felipe de Jesús
Bollain y Goytia, Juan José
Pacheco Tovar, Deyanira
Avalos Díaz, Esperanza del Refugio
Issue Date: Mar-2013
Publisher: Hindawi
Abstract: The present study investigated posttranslational reactions in the salivary glands of patients with Sjogren’s syndrome. We analysed the biopsies of primary Sjogren’s patients using immunohistochemistry and a tag-purified anticyclic citrullinated protein (CCP) antibody to detect citrullinated peptides, and the presence of peptidylarginine deiminase 2 (PAD2) was assessed simultaneously. The present work demonstrated the weak presence of the PAD2 enzyme in some normal salivary glands, although PAD2 expression was increased considerably in Sjogren’s patients. The presence of citrullinated proteins was also detected in the salivary tissues of Sjogren’s patients, which strongly supports the ¨ in situ posttranslational modification of proteins in this setting. Furthermore, the mutual expression of CCP and PAD2 suggests that this posttranslational modification is enzyme dependent. In conclusion, patients with Sjogren’s syndrome expressed the catalytic machinery to produce posttranslational reactions that may result in autoantigen triggering
ISSN: 2090-0430
Other Identifiers: info:eu-repo/semantics/publishedVersion
Appears in Collections:*Documentos Académicos*-- UA Medicina

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