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Title: Comparative Pathogenicity of Lomentospora prolificans (Scedosporium prolificans) Isolates from Mexican Patients
Authors: Elizondo Zertuche, Mariana
M. Montoya, Alexandra
Robledo Lea, Efrén
Garza Veloz, Idalia
Sánchez Núñez, Ana L.
Ballesteros Elizondo, Raquel
M. González, Gloria
Issue Date: 29-Apr-2017
Publisher: Springer
Abstract: We identified 11 Lomentospora prolificans isolates recovered from Mexican patients using phenotypic and molecular characteristics. The identification of isolates was assessed by internal transcribed spacer (ITS rDNA) sequencing. In vitro susceptibility to amphotericin B, fluconazole, voriconazole, posaconazole, caspofungin, anidulafungin and micafungin was determined according to Clinical and Laboratory Standards Institute (CLSI) procedures. Three isolates (07-2239, 11-2242 and 04-2673) were used to induce systemic infection in immunocompetent ICR mice. Survival and tissue burden studies were used as markers of pathogenicity. All of the strains were resistant to every antifungal tested with MIC’s for AmB (8–[8 lg/ml), VRC (16–[16 lg/ml), PSC (16– [16 lg/ml), FLC (64–[64 lg/ml) and echinocandins with MICs C8 lg/ml. One hundred, ninety and sixty percent of the infected mice with the strains 07-2239, 11-2242 and 04-2673 died during the study, respectively. Regarding tissue burden, the highest fungal load of the infected mice was detected in brain followed by spleen and kidney, regardless of the strain.
ISSN: 1573-0832
Other Identifiers: info:eu-repo/semantics/publishedVersion
Appears in Collections:*Documentos Académicos*-- Doc. en Ing. y Tec. Aplicada

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