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Title: Circulating levels of specific members of chromosome 19 microRNA cluster are associated with preeclampsia development
Authors: Martínez Fierro, Margarita de la Luz
Garza Veloz, Idalia
Gutierrez Arteaga, Christina
Delgado Enciso, Iván
Barbosa Cisneros, Olga Yadira
Flores Morales, Virginia
Hernández Delgadillo, Gloria Patricia
Rocha Pizaña, María del Refugio
Rodríguez Sánchez, Iram Pablo
Badillo Almaráz, José Isaías
Ortíz Rodríguez, José Manuel
Castañeda Miranda, Rodrígo
Solís Sánchez, Luis Octavio
OrtÍz Castro, Yolanda
Issue Date: 1-Dec-2017
Publisher: Springer
Abstract: Purpose: To perform serum microRNA expression profiling to identify members of chromosome 19 miRNA cluster involved in preeclampsia development. Methods: Serum chromosome 19 miRNA cluster microRNA expression profiling was evaluated at 12, 16, and 20 gestational weeks and at the time of preeclampsia diagnosis, in women who developed preeclampsia (WWD-PE; n = 16) and controls (n = 18) using TaqMan low density array plates. Results: A total of 51 chromosome 19 microRNA cluster members were evaluated. The circulating hsa-miRs 512-3p, 518f3p, 520c-3p, and 520d-3p, were differentially expressed between groups (P < 0.05). Compared with controls, serum levels of hsa-miR-518f-3p at 20 GW were useful for identifying WWD-Mild-PE (P = 0.035) and WWD-Severe-PE(P = 0.007). Conclusions: Serum hsa-miRs 512-3p, 518f-3p, 520c-3p, and 520d-3p, are differentially expressed between WWD-PE and controls and their role in the development of preeclampsia should be investigated further.
ISSN: 1432-0711
Other Identifiers: info:eu-repo/semantics/publishedVersion
Appears in Collections:*Documentos Académicos*-- Doc. en Ing. y Tec. Aplicada

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