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dc.contributor | 49237 | es_ES |
dc.contributor | 268446 | es_ES |
dc.coverage.spatial | Global | es_ES |
dc.creator | Luna Aguirre, Claudia Maribel | |
dc.creator | Martínez Fierro, Margarita de la Luz | |
dc.creator | Mar Aguilar, Fermín | |
dc.creator | Garza Veloz, Idalia | |
dc.creator | Treviño Alvarado, Víctor | |
dc.creator | Rojas Martínez, Augusto | |
dc.creator | Jaime Pérez, José Carlos | |
dc.creator | Malagon Santiago, Guadalupe Ismael | |
dc.creator | Gutiérrez Aguirre, César Homero | |
dc.creator | González Llano, Oscar | |
dc.creator | Salazar Riojas, Rosario | |
dc.creator | Hidalgo Miranda, Alfredo | |
dc.creator | Martínez Rodríguez, Herminia Guadalupe | |
dc.creator | Gómez Almaguer, David | |
dc.creator | Ortíz López, Rocío | |
dc.date.accessioned | 2020-03-31T20:49:40Z | |
dc.date.available | 2020-03-31T20:49:40Z | |
dc.date.issued | 2015 | |
dc.identifier | info:eu-repo/semantics/publishedVersion | es_ES |
dc.identifier.issn | 1574-0153 | es_ES |
dc.identifier.uri | http://ricaxcan.uaz.edu.mx/jspui/handle/20.500.11845/1481 | |
dc.description.abstract | BACKGROUND: Acute lymphoblastic leukemia (ALL) is a highly diverse disease characterized by cytogenetic and molecularabnormalities, including altered microRNA (miRNA) expression signatures. AIM: We perform and validate a plasma miRNA expression profiling to identify potential miRNA involved in leukemogenesis METHODS: MiRNA expression profiling assay was realized in 39 B-ALL and 7 normal control plasma samples using TaqMan Low Density Array (TLDA) plates on Applied Biosystems 7900 HT Fast Real-Time PCR System. MiRNA validation was done for six miRNA differentially expressed by quantitative real-time PCR. RESULTS: Seventy-seven circulating miRNA differentially expressed: hsa-miR-511, -222, and -34a were overexpressed, whereas hsa-miR-199a-3p, -223, -221, and -26a were underexpressed (p values < 0.005 for both sets). According to operating characteristic curve analysis, hsa-miR-511 was the most valuable biomarker for distinguishing B-ALL from normal controls,with an area under curve value of 1 and 100% for sensitivity, and specificity respectively. CONCLUSIONS: Measuring circulating levels of specific miRNA implicated in regulation of cell differentiation and/or cell proliferation such as hsa-miRNA-511, offers high sensitivity and specificity in B-ALL detection and may be potentially useful for detection of disease progression, as indicator of therapeutic response, and in the assessment of biological and/or therapeutic targets for patients with B-ALL. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | IOS Press | es_ES |
dc.relation | 10.3233/CBM-150465 | es_ES |
dc.relation.uri | generalPublic | es_ES |
dc.source | Cancer Biomarkers Vol. 15, pp. 299–310 | es_ES |
dc.subject.classification | INGENIERIA Y TECNOLOGIA [7] | es_ES |
dc.subject.other | Biomarkers | es_ES |
dc.subject.other | hematological malignancies | es_ES |
dc.subject.other | qRT-PCR | es_ES |
dc.subject.other | signaling pathway | es_ES |
dc.title | Circulating microRNA expression profile in B-cell acute lymphoblastic leukemia | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |