Please use this identifier to cite or link to this item: http://ricaxcan.uaz.edu.mx/jspui/handle/20.500.11845/588
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dc.contributor165500es_ES
dc.contributor43665es_ES
dc.contributor.otherhttps://orcid.org/0000-0002-1995-1696-
dc.contributor.otherhttps://orcid.org/0000-0001-6803-925X-
dc.contributor.otherhttps://orcid.org/0000-0002-2979-6159-
dc.coverage.spatialZacatecas, Méxicoes_ES
dc.creatorLazalde Ramos, Blanca Patricia-
dc.creatorGómez Meda, Belinda Claudia-
dc.creatorReyes Estrada, Claudia Araceli-
dc.creatorOrtíz García, Yveth Marlene-
dc.creatorZamora Pérez, Ana Lourdes-
dc.creatorGutiérrez Hernández, Rosalinda-
dc.creatorMorales Velazquez, Gabriela-
dc.creatorQuirarte Baez, Sol María-
dc.creatorZúñiga González, Moisés Zúñiga-
dc.date.accessioned2018-06-22T13:33:13Z-
dc.date.available2018-06-22T13:33:13Z-
dc.date.issued2018-04-03-
dc.identifierinfo:eu-repo/semantics/publishedVersiones_ES
dc.identifier.issn2379-6294es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.11845/588-
dc.identifier.urihttps://doi.org/10.48779/ab63-h106-
dc.descriptionRosmarinus officinalis is a common household aromatic plant widely used in cosmetic, food and folk medicine. The aim of this study was evaluated rosmarinus total extract (RTE) protective effect on DNA damage induced by cyclophosphamide (CP) and evidence the lack of genotoxicity and cytotoxicity of RTE in peripheral blood erythrocytes of Balb-C mice using the micronucleus assay. To evaluate the DNA protective effect, the dose of 100mg/kg of RTE was used and given orally. Following was the admiration of CP (50mg/kg). To evaluated the lack genotoxic or cytotoxic, three doses (30, 100 and 300mg/kg) of RTE were administered orally. A drop of blood was obtained from the tip of the tail of each mouse 24h for six days. We found no increase of micronucleated erythrocytes (MNE) or micronucleated polychromatic erythrocytes (MNPCE). Nor did polychromatic erythrocytes (PCE) decline in mice treated with one of the three different doses of RTE. RTE extracts were capable of diminished DNA damage caused by CP thus reducing MNE and MNPCE frequencies. The lack of genotoxic and cytotoxic effect of the RTE and reduces the genotoxicity caused by CP, suggest the potential therapeutic usefulness of this plant extract.es_ES
dc.description.abstractRosmarinus officinalis is a common household aromatic plant widely used in cosmetic, food and folk medicine. The aim of this study was evaluated rosmarinus total extract (RTE) protective effect on DNA damage induced by cyclophosphamide (CP) and evidence the lack of genotoxicity and cytotoxicity of RTE in peripheral blood erythrocytes of Balb-C mice using the micronucleus assay. To evaluate the DNA protective effect, the dose of 100mg/kg of RTE was used and given orally. Following was the admiration of CP (50mg/kg). To evaluated the lack genotoxic or cytotoxic, three doses (30, 100 and 300mg/kg) of RTE were administered orally. A drop of blood was obtained from the tip of the tail of each mouse 24h for six days. We found no increase of micronucleated erythrocytes (MNE) or micronucleated polychromatic erythrocytes (MNPCE). Nor did polychromatic erythrocytes (PCE) decline in mice treated with one of the three different doses of RTE. RTE extracts were capable of diminished DNA damage caused by CP thus reducing MNE and MNPCE frequencies. The lack of genotoxic and cytotoxic effect of the RTE and reduces the genotoxicity caused by CP, suggest the potential therapeutic usefulness of this plant extract.es_ES
dc.language.isoenges_ES
dc.publisherMedCrave Step into the world of researches_ES
dc.relationhttp://medcraveonline.com/MOJT/current-issuees_ES
dc.relation.ispartofhttp://medcraveonline.com/MOJT/current-issuees_ES
dc.relation.urigeneralPublices_ES
dc.rightsAtribución-NoComercial-CompartirIgual 3.0 Estados Unidos de América*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.sourceMOJ Toxicology Vol. 4, Núm. 2, pp. 75-79es_ES
dc.subject.classificationMEDICINA Y CIENCIAS DE LA SALUD [3]es_ES
dc.subject.othergenotoxicityes_ES
dc.subject.othercytotoxicityes_ES
dc.subject.othermicronucleuses_ES
dc.subject.otherDNA protective effectes_ES
dc.subject.otherrosmarinus total extractes_ES
dc.titleDNA protective effect of rosmarinus officinalis total extract in mouse peripheral bloodes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
Appears in Collections:*Documentos Académicos*-- UA Medicina

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