Please use this identifier to cite or link to this item: http://ricaxcan.uaz.edu.mx/jspui/handle/20.500.11845/2678
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dc.contributor46461es_ES
dc.contributor.otherhttps://orcid.org/0000-0002-1995-1696-
dc.coverage.spatialMéxicoes_ES
dc.creatorBailón Soto, Claudia-
dc.creatorGalaviz Hernández, Carlos-
dc.creatorLazalde Ramos, Blanca Patricia-
dc.creatorHernández Velázquez, Daniel-
dc.creatorSalas Pacheco, José-
dc.creatorLares Assef, Israel-
dc.date.accessioned2021-06-29T16:39:53Z-
dc.date.available2021-06-29T16:39:53Z-
dc.date.issued2014-07-
dc.identifierinfo:eu-repo/semantics/publishedVersiones_ES
dc.identifier.issn0188-4409es_ES
dc.identifier.urihttp://ricaxcan.uaz.edu.mx/jspui/handle/20.500.11845/2678-
dc.identifier.urihttps://doi.org/10.48779/ayg9-ee63-
dc.description.abstractBackground and Aims High triglyceride levels are closely related to cardiovascular disease. Its development lays on age, diet, physical activity, ethnicity and genetic factors. Among the last, the CYP1A1*2C allele has an influence on the metabolism of cholesterol and other fatty acids. We undertook this study to determine the frequency of CYP1A1*2C and its association with triglyceride levels in Mexican indigenous Tarahumaras and Tepehuanos. Methods Anthropometric and biochemical data were recorded. Genotyping of CYP1A1*2C by RT-PCR was done in 110 Tepehuano, 69 Tarahumara and 64 Mestizo. Results Significant differences in age, waist diameter, BMI, creatinine, glucose, cholesterol, triglycerides, HDL and VLDL measurements were found between Tarahumaras and Tepehuanos (p <0.05). Additionally, Tarahumara women showed the highest values of waist diameter, BMI and triglycerides (p <0.05). It was found that Tarahumaras showed a significant association between high triglyceride levels and CYP1A1*2C allele (OR = 2.57; 95% CI 1.12–5.88, p = 0.024) under a recessive inheritance model. However, the Tepehuano group showed a significant protective association between normal triglyceride levels and CYP1A1*2C polymorphism (OR = 0.28; 95% CI 0.10–0.80, p = 0.015) following a dominant inheritance model. The same pattern was observed after analysis with females of both ethnicities. Conclusion A significant association between CYP1A1*2C and high triglyceride levels in Amerindian Tarahumaras from Chihuahua has been found; this allele was significantly associated with normal triglyceride levels in Tepehuanos from Durango, Mexico. Further studies are needed to elucidate the genetic role of CYP1A1 in cardiovascular disease susceptibility.es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relationhttps://www.sciencedirect.com/science/article/abs/pii/S0188440914001118es_ES
dc.relation.ispartofhttps://doi.org/10.1016/j.arcmed.2014.05.007es_ES
dc.relation.urigeneralPublices_ES
dc.rightsAtribución-NoComercial-CompartirIgual 3.0 Estados Unidos de América*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.sourceArchives of Medical Research Volume 45, Issue 5, July 2014, Pages 409-416es_ES
dc.subject.classificationBIOLOGIA Y QUIMICA [2]es_ES
dc.subject.otherHigh triglyceride levelses_ES
dc.subject.otherTarahumarases_ES
dc.subject.otherTepehuanoses_ES
dc.subject.otherCYP1A1es_ES
dc.titleInfluence of CYP1A1*2C on High Triglyceride Levels in Female Mexican Indigenous Tarahumarases_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
Appears in Collections:*Documentos Académicos*-- M. en Ciencias y Tecnología Química



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