Please use this identifier to cite or link to this item: http://ricaxcan.uaz.edu.mx/jspui/handle/20.500.11845/2657
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dc.contributor46461es_ES
dc.coverage.spatialGlobales_ES
dc.creatorG. Naranjo, María-Eugenia-
dc.creatorRodrigues Soares, Fernanda-
dc.creatorPeñas Lledó, Eva M.-
dc.creatorTarazona Santos, Eduardo-
dc.creatorFariñas, Humberto-
dc.creatorRodeiro, Idania-
dc.creatorTerán, Enrique-
dc.creatorGrazina, Manuela-
dc.creatorE. Moya, Graciela-
dc.creatorLópez López, Marisol-
dc.creatorSarmiento, Alba P.-
dc.creatorCalzadilla, Luis R.-
dc.creatorRamírez Roa, Ronald-
dc.creatorOrtiz López, Rocío-
dc.creatorEstévez Carrizo, Francisco E.-
dc.creatorSosa Macías, Martha-
dc.creatorBarrantes, Ramiro-
dc.creatorLLerena, Adrián-
dc.creatorE. Moya, Graciela-
dc.creatorFcrreiro, Verónica-
dc.creatorTarazona Santos, Eduardo-
dc.creatorRodrigues Soares, Fernanda-
dc.creatorScliar, Marilia O.-
dc.creatorGouveia, Mateus H-
dc.creatorSarmiento, Alba P.-
dc.creatorBorbón, Angélica-
dc.creatorBarrantes, Ramiro-
dc.creatorJiménez Arce, Gerardo-
dc.creatorCéspedes Garro, Carolina-
dc.creatorRodeiro, Idania-
dc.creatorÁlvárez, Mayra-
dc.creatorDelgado, René-
dc.creatorRemirez, Diadelis-
dc.creatorPérez, Bárbaro-
dc.creatorCalzadilla, Luis R.-
dc.creatorTerán, Enrique-
dc.creatorHernández, Francisco-
dc.creatorTerán, Santiago-
dc.creatorOrtiz López, Rocío-
dc.creatorRojas Martinez, Augusto-
dc.creatorGarza Ocañas, Lourdes-
dc.creatorPérez Páramo, Yadira X.-
dc.creatorLópez López, Marisol-
dc.creatorOrtega Vázquez, Alberto-
dc.creatorMonroy Jaramillo, Nancy-
dc.creatorJung Cook, Helgi-
dc.creatorFricke Galindo, Ingrid-
dc.creatorSosa Macías, Martha-
dc.creatorGalaviz Hernández, Carlos-
dc.creatorLares Aseff, Ismael-
dc.creatorLazalde Ramos, Blanca P.-
dc.creatorRamírez Roa, Ronald-
dc.creatorAltamirano Tinoco, Catalina-
dc.creatorTarazona Santos, Eduardo-
dc.creatorZamudio, Roxana-
dc.creatorGilman, Robert H.-
dc.creatorGrazina, Manuela-
dc.creatorLLerena, Adrián-
dc.creatorCobaleda, Jesús-
dc.creatorde Andrés, Fernando-
dc.creatorDorado, Pedro-
dc.creatorFariñas, Humberto-
dc.creatorNaranjo, Eugenia G.-
dc.creatorPeñas Lledó, Eva M.-
dc.creatorEstévez Carrizo, Francisco E.-
dc.date.accessioned2021-06-24T20:44:49Z-
dc.date.available2021-06-24T20:44:49Z-
dc.date.issued2018-09-18-
dc.identifierinfo:eu-repo/semantics/publishedVersiones_ES
dc.identifier.issn1536-2310es_ES
dc.identifier.issn1557-8100es_ES
dc.identifier.urihttp://ricaxcan.uaz.edu.mx/jspui/handle/20.500.11845/2657-
dc.description.abstractPharmacogenetic variation in Latin Americans is understudied, which sets a barrier for the goal of global precision medicine. The RIBEF-CEIBA Network Consortium was established to characterize interindividual and between population variations in CYP2D6, CYP2C9, and CYP2C19 drug metabolizing enzyme genotypes, which were subsequently utilized to catalog their "predicted drug metabolism phenotypes" across Native American and Ibero American populations. Importantly, we report in this study, a total of 6060 healthy individuals from Ibero-America who were classified according to their self-reported ancestry: 1395 Native Americans, 2571 Admixed Latin Americans, 96 Afro-Latin Americans, 287 white Latin Americans (from Cuba), 1537 Iberians, and 174 Argentinean Ashkenazi Jews. Moreover, Native Americans were grouped into North-, Central-, and South Amerindians (from Mexico, Costa Rica, and Peru, respectively). All subjects were studied for the most common and functional CYP2D6, CYP2C9, and CYP2C19 allelic variants, and grouped as genotype-predicted poor or ultrarapid metabolizer phenotypes (gPMs and gUMs, respectively). Native Americans showed differences from each ethnic group in at least two alleles of CYP2D6, CYP2C9, and CYP2C19. Native Americans had higher frequencies of wild-type alleles for all genes, and lower frequency of CYP2D6*41, CYP2C9*2, and CYP2C19*17 (p < 0.05). Native Americans also showed less CYP2C19 gUMs than the rest of the population sample. In addition, differences within Native Americans (mostly North vs. South) were also found. The interethnic differences described supports the need for population-specific personalized and precision medicine programs for Native Americans. To the best of our knowledge, this is the largest study carried out in Native Americans and other Ibero-American populations analyzing CYP2D6, CYP2C9, and CYP2C19 genetic polymorphisms. Population pharmacogenomics is a nascent field of global health and warrants further research and education.es_ES
dc.language.isoenges_ES
dc.publisherMary Ann Liebert, Inc.es_ES
dc.relationhttps://home.liebertpub.com/publications/omics-a-journal-of-integrative-biology/43es_ES
dc.relation.ispartof10.1089/omi.2018.0114es_ES
dc.relation.urigeneralPublices_ES
dc.rightsAtribución-NoComercial-CompartirIgual 3.0 Estados Unidos de América*
dc.rightsAtribución-NoComercial-CompartirIgual 3.0 Estados Unidos de América*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.sourceOMICS: A Journal of Integrative Biology Vol. 25, No. 6es_ES
dc.subject.classificationBIOLOGIA Y QUIMICA [2]es_ES
dc.subject.otherAmerindianses_ES
dc.subject.otherCYP2C19es_ES
dc.subject.otherCYP2C9es_ES
dc.subject.otherCYP2D6es_ES
dc.subject.otherLatin Americanses_ES
dc.subject.otherdrug metabolismes_ES
dc.subject.otherpharmacogeneticses_ES
dc.subject.otherprecision medicinees_ES
dc.titleInterethnic Variability in CYP2D6, CYP2C9, and CYP2C19 Genes and Predicted Drug Metabolism Phenotypes Among 6060 Ibero- and Native Americans: RIBEF-CEIBA Consortium Report on Population Pharmacogenomicses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
Appears in Collections:*Documentos Académicos*-- M. en Ciencias y Tecnología Química

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