Please use this identifier to cite or link to this item: http://ricaxcan.uaz.edu.mx/jspui/handle/20.500.11845/2174
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dc.contributor84378es_ES
dc.contributor4495es_ES
dc.contributor4494es_ES
dc.contributor.otherhttps://orcid.org/0000-0002-3403-9849-
dc.coverage.spatialGlobales_ES
dc.creatorBollain y Goytia, Juan José-
dc.creatorArellano Rodríguez, Mariela-
dc.creatorTorres del Muro, Felipe de Jesús-
dc.creatorDaza Benitez, Leonel-
dc.creatorMuñoz Valle, José Francisco-
dc.creatorAvalos Díaz, Esperanza del Refugio-
dc.creatorHerrera Esparza, Rafael-
dc.date.accessioned2020-12-03T16:42:33Z-
dc.date.available2020-12-03T16:42:33Z-
dc.date.issued2014-11-
dc.identifierinfo:eu-repo/semantics/publishedVersiones_ES
dc.identifier.issn2090-214Xes_ES
dc.identifier.issn2090-2158es_ES
dc.identifier.urihttp://ricaxcan.uaz.edu.mx/jspui/handle/20.500.11845/2174-
dc.identifier.urihttps://doi.org/10.48779/nwst-k854-
dc.description.abstractThis study was performed to clarify the role of soluble Fas (sFas) in lupus nephritis (LN) and establish a potential relationship between LN and the −670 polymorphism of Fas in 67 patients with systemic lupus erythematosus (SLE), including a subset of 24 LN patients with proteinuria. Additionally, a group of 54 healthy subjects (HS) was included. The allelic frequency of the−670 polymorphism of Fas was determined using PCR-RFLP analysis, and sFas levels were assessed by ELISA. Additionally, the WT-1 protein level in urine was measured. The Fas receptor was determined in biopsies by immunohistochemistry (IHC) and in situ hybridization (FISH) and apoptotic features by TUNEL. Results. The −670 Fas polymorphism showed that the G allele was associated with increased SLE susceptibility, with an odds ratio (OR) of 1.86. The sFas was significantly higher in LN patients with the G/G genotype, and this subgroup exhibited correlations between the sFas level and proteinuria and increased urinary WT1 levels. LN group shows increased expression of Fas and apoptotic features. In conclusion, our results indicate that the G allele of the −670 polymorphism of Fas is associated with genetic susceptibility in SLE patients with elevated levels of sFas in LN with proteinuria.es_ES
dc.language.isospaes_ES
dc.publisherHindawies_ES
dc.relationhttps://www.hindawi.com/journals/ijn/2014/780406/es_ES
dc.relation.ispartofhttps://doi.org/10.1155/2014/780406es_ES
dc.relation.urigeneralPublices_ES
dc.rightsAtribución-NoComercial-CompartirIgual 3.0 Estados Unidos de América*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.sourceInternational Journal of Nephrology Volume 2014, Article ID 780406, 10 páginases_ES
dc.subject.classificationMEDICINA Y CIENCIAS DE LA SALUD [3]es_ES
dc.subject.otherlupus nephritis (LN)es_ES
dc.subject.othersoluble Fas (sFas)es_ES
dc.subject.othersystemic lupus erythematosus (SLE)es_ES
dc.titleSoluble Fas and the −670 Polymorphism of Fas in Lupus Nephritises_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
Appears in Collections:*Documentos Académicos*-- UA Medicina

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