Ochoa González, Fátima de Lourdes; González Curiel, Irma Elizabeth; Cervantes Villagrana, Alberto Rafael; Fernández Ruiz, Julio Cesar; Castañeda Delgado, Julio Enrique
Resumen:
Diabetes is a chronic disease characterized by marked alterations in the
metabolism of glucose and by high concentrations of glucose in the blood due to a
decreased insulin production or resistance to the action of this hormone in peripheral
tissues. The International Diabetes Federation estimates a global incidence of diabetes
of about 10% in the adult population (20 - 79 years old), some 430 million cases
reported worldwide in 2018. It is well documented that people with diabetes have a
higher susceptibility to infectious diseases and therefore show higher morbidity and
mortality compared to the non-diabetic population. Given that the innate immune
response plays a fundamental role in protecting against invading pathogens through a
myriad of humoral and cellular mechanisms, the present work makes a comprehensive
review of the innate immune alterations in patients with type 2 diabetes mellitus (T2D) as
well as a brief description of the molecular events leading or associated to such
conditions. We show that in these patients a compromised innate immune response
increases susceptibility to infections.