Leyva Ramos, Socorro; Hernández López, Hiram; Jiménez Cataño, Rogelio; Chacón García, Luís; Vega Rodríguez, Sarai
Resumen:
Most of the quinolone antibacterial research has
been focused on the functionality at C-7 position where the
nature of substituents is responsible for antibacterial
spectrum, potency, bioavailability, and side effects of the
quinolones. Then, a 7-amino-fluoroquinolone could be the
starting point of a wide variety of potentially useful compounds like tetracyclic and tricyclic quinolones or secondary amines with side chain derivatives. This attracted
our attention to synthesize a 7-azide-fluoroquinolone,
which could be converted to amine performing a photochemical reaction using CuI as catalyst. FT-IR and H1
NMR spectra of the final product, ethyl 7-amino-1-ethyl6,8-difluoroquinolone-3-carboxylate, suggests the formation of dimers, a feature already observed in norfloxacin.