http://ricaxcan.uaz.edu.mx/jspui/handle/20.500.11845/313 2026-04-06T01:33:25Z http://ricaxcan.uaz.edu.mx/jspui/handle/20.500.11845/3271 Título : Burnout y autocuidado en médicos de una Unidad de Medicina Familiar en Zacatecas Authors: Ruiz de Chávez Ramírez, Dellanira; Pando Moreno, Manuel; Almeida Perales, Cristina; García Zamora, Pascual Gerardo Resumen : El Síndrome de Burnout representa una disminución de los sentimientos de competencia y desempeño exitoso, con una serie de respuestas negativas hacia uno mismo, así como para el trabajo, donde aparece un incremento de irritabilidad, tensión, depresión y aislamiento de las relaciones profesionales. Una de las condiciones para que ocurra tal síndrome es el aburrimiento, la rutina y la monotonía en el trabajo, que aparecen una vez perdido el entusiasmo inicial, generalmente después de un año del inicio en un trabajo. El objetivo del presente estudio es identificar la prevalencia del síndrome de burnout y acciones de autocuidado en médicos de una unidad de medicina familiar ya que son los que se encuentran en el primer nivel de atención y son los principales educadores y promotores de la salud desafortunadamente muchas de las ocasiones otorgan indicaciones para el correcto autocuidado, pero en la vida personal no los practican ni las ejemplifican con su estado de salud general. Descripción : The Burnout Syndrome represents a decrease in the feelings of competence and successful performance, with a series of negative responses towards oneself, as well as for work, where an increase of irritability, tension, depression and isolation professional relationships One of the conditions for such a syndrome occurs is boredom, routine and monotony at work, which appear once the initial enthusiasm. The objective of this study is to identify the prevalence of burnout syndrome and actions of self-care in doctors of a family medicine unit since they are the ones that are in the first level of attention and are the main educators and promoters of health unfortunately many of the occasions give indications for correct self-care, but in the personal life do not practice them or exemplify them with their general health status. 2014-05-15T00:00:00Z http://ricaxcan.uaz.edu.mx/jspui/handle/20.500.11845/2191 Título : L’Apoptosis e la necrosi aumentano l’antigenicità di proteine riconosciute dagli anticorpi antinucleari Authors: Herrera VanOostdam, David Alejandro; Esparza Ibarra, Edgar de León; Ramírez Sandoval, Roxana; Ortíz, V.; Bollain y Goytia, Juan José; Avalos Díaz, Esperanza del Refugio; Herrera Esparza, Rafael Resumen : Obiettivo. Lo scopo di questo studio è quello di indagare se l’apoptosis e la necrosi aumentano l’antigenicità delle proteine riconosciute da anticorpi antinucleo. Materiale e metodi. Cellule HEp-2 sono state coltivate in condizioni standard; l’apoptosis è stata indotta con camptecina e la necrosi con cloruro di mercurio. L’antigenicità delle proteine estratte dalle cellule è stato testata su membrane di nitrocellulosa e sondata con sieri positivi o negativi per anticorpi antinucleo utilizzando un sistema ELISA a luminescenza (luminescent). Risultati. Le alterazioni apoptotiche nelle cellule HEp-2 sono apparse entro 24 ore dall’esposizione alla camptoicina, mentre i segni di necrosi si sono evidenziati più precocemente. La luminescenza si è dimostrata significativamente superiore nei sieri ANA positivi che nei controlli ANA negativi. Gli antcorpi antinucleari sieirici riconoscono meglio gli antigeni da cellule apoptotiche e necrotiche rispetto ai controlli che non hanno subito trattamenti chimici. Conclusioni. L’apoptosi e la necrosi incrementano la capacità legante degli ANA attraverso una migliore disponibilità di antigeni intracellulari o svelando epitopi criptici. 2004-01-01T00:00:00Z http://ricaxcan.uaz.edu.mx/jspui/handle/20.500.11845/2190 Título : Pathogenic effects of maternal antinuclear antibodies during pregnancy in women with lupus Authors: Herrera Esparza, Rafael; Bollain y Goytia, Juan José; Avalos Díaz, Esperanza del Refugio Resumen : Lupus is an autoimmune disease that primarily affects young women of childbearing age. Fertility rates in lupus patients depend on various factors, including disease activity, nephritis, and the presence of antiphospholipid antibodies; however, after lupus patients become pregnant, different factors may affect the course of pregnancy, such as the production of autoantibodies, pre-existing renal disease, and eclampsia, among others. The placenta is a temporary hemochorial organ that prevents immunological conflict due to exposure to alloantigens at the maternal-fetal interface; placental regulatory T cells play a major role in maternal-fetal tolerance. Typically, significant amounts of maternal IgG class antibodies cross the placenta and enter the fetal circulation. This transition depends on the distribution of Fc receptors along the syncytiotrophoblast. The production of antinuclear antibodies (ANA) is a hallmark of lupus, and these autoantibodies can form immune complexes that are typically trapped in the placenta during gestation. However, the entry of ANA into the fetal circulation depends on the IgG-ANA concentration and the FcR placental density. Maternal antinuclear antibodies with anti-Ro or anti-La specificity might be pathogenic to the fetus if transfused by the placental pathway and could induce neonatal pathologies, such as neonatal lupus and congenital heart block. Here, we review the experimental and clinical data supporting a pathogenic role for maternal autoantibodies transmitted to the fetus. 2014-01-01T00:00:00Z http://ricaxcan.uaz.edu.mx/jspui/handle/20.500.11845/2189 Título : Camptothecin induces the transit of fASl trimers to the cell surface in apoptotic heP-2 cells Authors: Meza Lamas, Esteban; Bollain y Goytia, Juan José; Ramírez Sandoval, Roxana; Sánchez Rodríguez, Sergio; López Robles, Erendira; Avalos Díaz, Esperanza del Refugio; Herrera Esparza, Rafael Resumen : Fas ligand (L) is a membrane protein from the tumor necrosis factor (TNF) family. It induces apoptosis upon contact with its Fas/CD95/APO1 receptor. Trimerization of FasL on the surface of effector cells is essential in the binding of the Fas trimer of the target cells. The receptor then recruits an adaptor and caspase-like proteins which lead apoptosis. This paper reports on the fate of FasL in HEp-2 cells committed to apoptosis by induction with campthotecin. Our main results demonstrated that in non-apoptotic cells, FasL aggregates in the cytoplasm forming trimers of 120 kDa. Apoptosis increases the trimeric FasL species, but also induces its dissociation into monomers of 35 kDa. In conclusion, camptothecin appears to perturb the Fas and FasL segregation in the cytoplasm by promoting the transit of FasL to the cell surface, thus fostering a process of autocrine or paracrine apoptosis. FasL is trimerized prior to Fas/FasL complex formation, and after apoptosis, FasL undergoes an intense turnover. 2006-04-19T00:00:00Z